Contamination risks As the preservative system degrades over time, its ability to suppress microbial growth diminishes
Mutagenesis of any of the metal ligands, notably the single thiolate ligand, C384 (Figure 4C) disrupts metal binding, and induces a thermal destabilization on par with metal removal by EDTA
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Kinetic complementarity: The different half-lives (BPC-157 ~30 min vs TB-500 ~2-3 h) produce a layered tissue-repair signal: BPC-157 initiates early VEGF and angiogenic priming, while TB-500 sustains the cellular migration window for hours afterward
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